#4504 QUANTITATIVE CHANGES IN INTRACARDIAC FLOW PARAMETERS DURING HEMODIALYTIC SESSIONS

Abstract Background and Aims Hemodialysis sessions exert an acute impact on cardiac geometry mechanics. The recent development of quantitative measurement intracardiac fluid-dynamics analysis vortexes offers a new opportunity to better understand the fine changes in hemodynamic associated with hemodialysis sessions. Vortexes rise chambers from blood flow they are defined as circular fluid structures rotational movement around central virtual axis, capable storing kinetic energy during rotation. They must be distinguished turbulences, which various different sizes coexist chaotically, resulting rapid dissipation energy. Our aim was assess hemodialytic session parameters originated dynamics. Method We included 26 consecutive patients chronic clinically stable phase. underwent echocardiography including fluid-dynamic by Color Vector Flow Mapping (Hyperdoppler) before after single dialysis session(Fig. 1-A). Patients hemodynamically relevant valvular disease were excluded. A complete evaluation multiple such vortex area (VA); length (VL); depth (VD). Bland Altman Plot has been used intra inter-observer variability. Changes dynamics tested using Wilcoxon matched-pairs test. Results Mean Vortex Area (VA) (p = 0.034) (Fig. 1-B), Depth (VD) 0.024) 1-C) Length (L) 0.037) 1-D) significantly reduced session. similar trend towards reduction Direct (DF) parameter found, larger for baseline left ventricular (V) end-diastolic diameter (r 0.446; p 1-E). On other hand, mean Intensity (VI) increased 0.046) 1-F). Among parameters, intradialytic change Kinetic Energy Fluctuation (KEF) 0.4; 0.058) Shear Stress (SSF) 0.435; 0.038) 1-G) most closely correlated weight change. Fluid dynamic had trends change, stronger correlations among geometric parameters. Delta VA related VI (p<0.001) or LV (p<0.001). also VL Dissipation (KED) 0.030), 0.044). KEF KED 0.001) SSF ( 0.022). Finally, those Force Parameter 0.033) Angle 0.034), that very each Conclusion This is first study assessing haemodialytic Measurement hyperdoppler indices haemodialysis chair feasible reliable whole population. results uncovered echocardiographic haemodialysis.